_The first comprehensive one-volume collection of St.Thomas More’s writing__ “[A] tremendous scholarly undertaking.... Accessible and transparent to both scholars and the general audience.”—_Renaissance and Reformation__ In this book, Wegemer and Smith assemble More’s most important English and Latin works for the first time in a single volume. This volume reveals the breadth of More’s writing and includes a rich selection of illustrations and artwork. The book provides the most complete picture of More’s work available, serving as a major resource for (...) early modern scholars, teachers, students, and the general reader. (shrink)

The purpose of this study was to investigate how the subjective impression of English speech would change when pause duration at punctuation marks was varied. Two listening experiments were performed in which written English speech segments were rated on a variety of evaluation items by both native-English speakers and non-native speakers. The ratings were then subjected to factor analysis. In the first experiment, the pauses in three segments were made into the same durations, from 0.075 to 4.8 s. Participants rated (...) the segments on 23 evaluation items on a rating scale from 1 to 10. A varimax rotation after PCA led to two factors that were related to speech style. These two factors could be interpreted as representing speech naturalness and speech rate. Speech segments with a pause duration of 0.6 s received the highest naturalness evaluation, while perceived speech rate decreased as the physical pause duration increased, without any changes in utterance segments. In the second experiment, a full-factorial design of pause durations within and between sentences, i.e., for commas and for periods, was implemented in two speech segments. The original speech segments and speech segments without any pauses were also included as control conditions. From ratings on 12 evaluation items, similar to Experiment 1, two factors representing speech naturalness and speech rate were obtained. The results showed again that the perceived speech rate decreased with an increase only in pause duration. As for speech naturalness, the highest evaluations occurred when pause durations were 0.6 s within sentences, and either 0.6 or 1.2 s between sentences. This recommends fixing all pause durations to 0.6 s as a practical way to train non-native speakers to make their spoken English appear more natural. (shrink)

What were Shakespeare's final thoughts on history, tragedy, and comedy? Shakespeare's Last Plays focuses much needed scholarly attention on Shakespeare's "Late Romances." The work--a collection of newly commissioned essays by leading scholars of classical political philosophy and literature--offers careful textual analysis of Pericles, Prince of Tyre, Cymbeline, The Winter's Tale, The Tempest, All is True, and The Two Noble Kinsmen. The essays reveal how Shakespeare's thought in these final works compliments, challenges, fulfills, or transforms previously held conceptions of the playwright (...) and his political-philosophical views. (shrink)

Scientific breakthroughs rarely yield the potential to engage a foundational ethical question. Recent studies on direct reprogramming of human skin cells reported by the Yamanaka lab in Japan and the Thomson lab in Wisconsin suggest that scientists may have crossed both a scientific and an ethical threshold. The fascinating science of direct nuclear reprogramming highlights empirical data that may clarify the ontological status of cellular activity in the early stages of what could become a human fetus and justify ethical options (...) for research in this controversial field. The ontological and ethical implications that accrue here are connected with the biological or natural potentiality of these cells. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Direct Nuclear Reprogramming: Response to Condic, Lee, and GeorgeGerard Magill, Ph.D. and William B. NeavesWe read with great interest the response of Maureen Condic, Patrick Lee, and Robert George (2009) to our essay, “Ontological and Ethical Implications of Direct Nuclear Reprogramming” in the March 2009 issue of the Kennedy Institute of Ethics Journal (Magill and Neaves 2009). Much of their response addressed issues that are not in dispute: somatic (...) cells are not zygotes, neurons and hepatocytes are different, growth-factor signals from the trophoblast influence development of the inner cell mass, membranes derived from the trophectoderm are critically required for embryonic survival, and stem cells cannot produce a fetus “on their own.”The crucial point of disagreement deals with the fact that iPS cells are not totipotent but zygotes are. Zygotes can generate their own placental structures while iPS cells must be given them through tetraploid complementation. Condic, Lee, and George consider totipotency to be crucial to natural potentiality. We present an alternative view in our essay (Magill and Neaves 2009, pp. 28–29). Placental structures make no lasting contribution to the postnatal organism, and the equivalency of iPS cells with the inner cell mass of the blastocyst is apparent from tetraploid complementation experiments.The respondents acknowledge the following:... somatic cells can be “converted” into zygotes by the process of somatic cell nuclear transfer (SCNT) or direct reprogramming in combination with tetraploid complementation—just as sperm and egg cells can be “converted” into a zygote by the process of natural fertilization—....(Condic, Lee, and George 2009, p. 35)As the respondents recognize, different ways of manipulating cells can lead to embryogenesis: sperm and egg cells in the process of natural fertilization, the enucleated egg and an ordinary body cell in the process of somatic cell nuclear transfer, and reprogrammed skin cells and a tetraploid blastocyst in the case of induced pluripotent stem (iPS) cells. In each case, different cells are manipulated—or “converted” in the respondents’ terminology—in a process that alters their biological fate within a supportive environment facilitating embryogenesis.The developmental potential that resides in the human genome does not unfold in isolation, not even in a zygote. In all cases, whether involving a zygote or an iPS cell, interaction with a supportive environment is required to express the developmental program residing in the genome. [End Page 201]This biological reality supports what we have described as “early cellular development along the continuum of natural potentiality that can result in the formation of a fetus” (Magill and Neaves 2009, p. 30), and it presents a significant challenge to the natural potentiality argument.Gerard MagillVernon F. Gallagher Chair for the Integration of Science, Theology, Philosophy, and Law, and Professor, Center for Healthcare Ethics Duquesne University Pittsburgh, PA.William B. NeavesPresident and CEO Stowers Institute for Medical Research and Professor of Basic Medical Science University of Missouri at Kansas City School of Medicine Kansas City, MOReferencesCondic, Maureen L.; Lee, Patrick; and George, Robert P. 2008. Ontological and Ethical Implications of Direct Nuclear Reprogramming: Response to Magill and Neaves. Kennedy Institute of Ethics Journal 19: 33–40. Google ScholarMagill, Gerard, and Neaves William B. 2009. Ontological and Ethical Implications of Direct Nuclear Reprogramming. Kennedy Institute of Ethics Journal 19: 23–32. Google ScholarCopyright © 2009 The Johns Hopkins University Press... (shrink)

In this article, we argue that the scope of bioethical debate concerning justice in health should expand beyond the topic of access to health care and cover such issues as occupational hazards, safe housing, air pollution, water quality, food and drug safety, pest control, public health, childhood nutrition, disaster preparedness, literacy, and many other environmental factors that can cause differences in health. Since society does not have sufficient resources to address all of these environmental factors at one time, it is (...) important to set priorities for bioethical theorizing and policy formation. Two considerations should be used to set these priorities: (1) the impact of the environmental factor on health inequality, and (2) the practicality of addressing the factor. (shrink)

This handbook presents a comprehensive introduction to the core areas of philosophy of education combined with an up-to-date selection of the central themes. It includes 95 newly commissioned articles that focus on and advance key arguments; each essay incorporates essential background material serving to clarify the history and logic of the relevant topic, examining the status quo of the discipline with respect to the topic, and discussing the possible futures of the field. The book provides a state-of-the-art overview of philosophy (...) of education, covering a range of topics: Voices from the present and the past deals with 36 major figures that philosophers of education rely on; Schools of thought addresses 14 stances including Eastern, Indigenous, and African philosophies of education as well as religiously inspired philosophies of education such as Jewish and Islamic; Revisiting enduring educational debates scrutinizes 25 issues heavily debated in the past and the present, for example care and justice, democracy, and the curriculum; New areas and developments addresses 17 emerging issues that have garnered considerable attention like neuroscience, videogames, and radicalization. The collection is relevant for lecturers teaching undergraduate and graduate courses in philosophy of education as well as for colleagues in teacher training. Moreover, it helps junior researchers in philosophy of education to situate the problems they are addressing within the wider field of philosophy of education and offers a valuable update for experienced scholars dealing with issues in the sub-discipline. Combined with different conceptions of the purpose of philosophy, it discusses various aspects, using diverse perspectives to do so. Contributing Editors: Section 1: Voices from the Present and the Past: Nuraan Davids Section 2: Schools of Thought: Christiane Thompson and Joris Vlieghe Section 3: Revisiting Enduring Debates: Ann Chinnery, Naomi Hodgson, and Viktor Johansson Section 4: New Areas and Developments: Kai Horsthemke, Dirk Willem Postma, and Claudia Ruitenberg. (shrink)

From the opening of trade with Britain in the 1850s, Japan occupied a unique and contradictory place in the Victorian imagination, regarded as both a rival empire and a cradle of exquisite beauty. Quaint, Exquisite explores the enduring impact of this dramatic encounter, showing how the rise of Japan led to a major transformation of Western aesthetics at the dawn of globalization. Drawing on philosophy, psychoanalysis, queer theory, textual criticism, and a wealth of in-depth archival research, Grace Lavery provides (...) a radical new genealogy of aesthetic experience in modernity. She argues that the global popularity of Japanese art in the late nineteenth century reflected an imagined universal standard of taste that Kant described as the "subjective universal" condition of aesthetic judgment. The book features illuminating cultural histories of Gilbert and Sullivan's Mikado, English derivations of the haiku, and retellings of the Madame Butterfly story, and sheds critical light on lesser-known figures such as Winnifred Eaton, an Anglo-Chinese novelist who wrote under the Japanese pseudonym Onoto Watanna, and Mikimoto Ryuzo, a Japanese enthusiast of the Victorian art critic John Ruskin. Lavery also explains the importance and symbolic power of such material objects as W. B. Yeats's prized katana sword and the "Japanese vellum" luxury editions of Oscar Wilde. Quaint, Exquisite provides essential insights into the modern understanding of beauty as a vehicle for both intimacy and violence, and the lasting influence of Japanese forms today on writers and artists such as Quentin Tarantino. (shrink)

Recent developments in agriculture have stirred up interest in the concept of “sustainable” farming systems. Still it is difficult to determine the extent to which certain agricultural practices can be considered sustainable or not. Aiming at identifying the necessary attributes with respect to sustainability in Dutch dairy farming in the beginning of the third millennium, we first compiled a list of attributes referring to all farming activities with their related side effects with respect to economic, internal social, external social, and (...) ecological sustainability. A wide range of people (i.e., experts and stakeholders) were consulted to contribute to our list of attributes. Our consultation showed that only one attribute was selected for economic and internal social sustainability: profitability and working conditions, respectively. The list for external social sustainability contained 19 attributes and the list for ecological sustainability contained 15 attributes. To assess their relative importance, the same experts and stakeholders ranked the attributes for external social and ecological sustainability by using a questionnaire. The most important attributes for external social sustainability were food safety, animal health, animal welfare, landscape quality, and cattle grazing. For ecological sustainability they were eutrophication, groundwater pollution, dehydration of the soil, acidification, and biodiversity. The present method for identifying and ranking attributes is universal and, therefore, can be used for other agricultural sectors, for other countries, and for other time periods. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

This book assesses how Vatican II opened up the Catholic Church to encounter, dialogue, and engagement with other world religions. Opening with a contribution from the President of the Pontifical Council for Interreligious Dialogue, Cardinal Jean-Louis Tauran, it next explores the impact, relevance, and promise of the Declaration Nostra Aetate before turning to consider how Vatican II in general has influenced interfaith dialogue and the intellectual and comparative study of world religions in the postconciliar decades, as well as the contribution (...) of particular past and present thinkers to the formation of current interreligious and comparative theological methods. Additionally, chapters consider interreligious dialogue vis-à-vis theological anthropology in conciliar documents; openness to the spiritual practices of other faith traditions as a way of encouraging positive interreligious encounter; the role of lay and new ecclesial movements in interreligious dialogue; and the development of Monastic Interreligious Dialogue. Finally, it includes a range of perspectives on the fruits and future of Vatican’s II’s opening to particular faiths such as Judaism, Islam, Hinduism, and Buddhism. (shrink)

Gelfand quantales are complete unital quantales with an involution, *, satisfying the property that for any element a, if a b a for all b, then a a* a = a. A Hilbert-style axiom system is given for a propositional logic, called Gelfand Logic, which is sound and complete with respect to Gelfand quantales. A Kripke semantics is presented for which the soundness and completeness of Gelfand logic is shown. The completeness theorem relies on a Stone style representation theorem for (...) complete lattices. A Rasiowa/Sikorski style semantic tableau system is also presented with the property that if all branches of a tableau are closed, then the formula in question is a theorem of Gelfand Logic. An open branch in a completed tableaux guarantees the existence of an Kripke model in which the formula is not valid; hence it is not a theorem of Gelfand Logic. (shrink)

This paper focuses on how the practitioners of the exact and natural sciences can make a contribution to the project of the social sciences to break free of a reductive Eurocentrism in order to achieve a renewed universalism. Focusing in particular on the last 50 years, the paper: a) describes the 1955–60 turning point that can be perceived in techno-scientific development and its relationship with society; b) analyzes technical developments under the two modes of gigantism and miniaturization, putting them in (...) close relation with the political evolution of the world (Cold War and post-Cold War era) as well as with the phenomena of divergence/convergence among disciplines; c) explains the 'ethical movement in science' namely by introducing the idea of moral revaluation defined by similarity/contrast with the older and now well-accepted concept of scientific revolution; and d) sketches a typology of the scientific community's varied responses to the growing social protests around topics such as nuclear installations, health crises, genetically modified organisms, nanotechnologies and so on. (shrink)

Before I come to Professor Anderson’s objections to the argument in question, I should like to clarify just a few points. The argument that I presented is taken immediately from Mortimer Adler’s presentation of it, so let us call it ‘Adler’s Argument,’ though in fact its origins go all the way back to Aristotle. My reading of Adler’s presentation of the argument was that he gave it in two different forms, one categorical, the other hypothetical. Both forms of the argument, (...) of course, have effectively the same conclusion, which is, in the case of its categorical version, that “concepts are not physical beings” [proposition 3 for Professor Anderson] and, in the case of its hypothetical version, that “A concept is not an act of a bodily organ” [proposition 6 for Professor Anderson]. Now Adler concludes immediately from propositions 3/6 that “the power of conceptual thought is an immaterial power.” I argued in my original article that it was not obvious that this proposition was equivalent to propositions 3/6 and so I presented an additional argument to the bridge the gap [propositions a, b, c and d for Professor Anderson]. Let us call this ‘Casey’s Addendum.’. (shrink)

Our aim in this paper is to argue that empathy is an intellectual virtue. Empathy enables agents to gain insight into other people’s emotions and beliefs. The agent who possesses this trait is: (i) driven to engage in acts of empathy by her epistemic desires; (ii) takes pleasure in doing so; (iii) is competent at the activity characteristic of empathy; and, (iv) has good judgment as to when it is epistemically appropriate to engage in empathy. After establishing that empathy meets (...) all the necessary conditions to be classified as an intellectual virtue, we proceed to discuss Battaly’s argument according to which empathy is a skill rather than a virtue. We contend, contra Battaly, that the agent who possesses the virtue of empathy: (a) sometimes foregoes opportunities to engage in the activity characteristic of empathy because it is the virtuous thing to do, (b) does not make deliberate errors, and (c) her actions are always ultimately aiming at epistemic goods. (shrink)

Two alternative accounts of quantum spontaneous symmetry breaking (SSB) are compared and one of them, the decompositional account in the algebraic approach, is argued to be superior for understanding quantum SSB. Two exactly solvable models are given as applications of our account -- the Weiss-Heisenberg model for ferromagnetism and the BCS model for superconductivity. Finally, the decompositional account is shown to be more conducive to the causal explanation of quantum SSB.

Thomas F. Yarnall’s 2003 categories of ‘modernist’ and ‘traditionist’, used to classify accounts of the origins of engaged Buddhism, have proven useful as methodological tools but today need considerable reevaluation. This article investigates two more recent accounts dealing with engaged Buddhism — David Loy’s The Great Awakening and Sallie B. King’s Socially Engaged Buddhism — in order to critique and ultimately to go beyond Yarnall’s categories. It touches on questions concerning the legitimacy and obligations of scholars in defining Buddhism for (...) practitioners and for fellow academics, and makes the case that a significant shift is needed in order to avoid problems of Orientalism at work in some academic accounts of engaged Buddhism. (shrink)

Most attempts at obtaining theories that unify quantum mechanics with general relativity require violation of locality and/or causality to some degree. Here, we suggest that these problems actually are very deep and fundamental; hence they may require reconsideration of both quantum mechanics and general relativity at a very fundamental level. An approach called ‘deterministic quantisation’ is sketched.

Voici le premier livre, non seulement d'un fils de libraire, mais le premier livre fils des livres. Le De antiquissima sapientia italorum (1710) élève en effet soudainement à la hauteur métaphysique ce qui se préparait depuis dix ans dans les Discours inauguraux, et en particulier dans le dernier de ceux-ci, De la méthode des études de notre temps : L'union de la philologie et de la philosophie pour mener LE combat avec Descartes. On sait qu'il durera quinze ans pour Vico (...) (jusqu'à l'assaut final de la Scienza nuova en 1725). On sait aussi (au moins depuis l'essai de B. Croce de 1910, relayé en Allemagne par Windelband à partir de la 5e édition de sa Geschichte der neueren Philosophie, Leipzig, 1911, qui sortirent le Napolitain d'un oubli dont le "rayonnement" français était la cause principale) que ce combat ne s'arrêtera plus : venue de Platon et d'Aristote, mais aussi de tous les Latins (de Plaute, entre autres, dont le Cogito apparaît littéralement le "Sosie"), à travers les écoles scottiste et ockhamienne, passant ensuite par Marsile Ficin et Cardan, la pensée vichienne puise dans le trésor des langues la force de libérer la pensée moderne de ses limites cartésiennes, inaugurant une sorte de deuxième tradition (qui pourrait bien être la reprise de la modernité au sein de LA tradition, tout simplement). Reprise critique et extension en même temps, puisque, du centre métaphysique que constitue la pensée du VERUM IPSUM FACTUM, la pensée philologue s'étend, avant Rousseau, avant Nodier, avant Hegel, sur les langues, sur le droit, sur l'histoire. Non sans préfigurer (ce qui n'a pas été montré encore, malgré certaines prémonitions de Croce) la critique kantienne elle-même. Autant dire que notre temps appartient à ce livre et que Vico est bien, comme le nommait Gœthe, "der Altvater". (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:From the Perspective of the Self: Montaigne’s Self-PortraitPatrick HenryFrom the Perspective of the Self: Montaigne’s Self-Portrait, by Craig B. Brush; 321 pp. New York: Fordham University Press, 1994, $32.50.In a note to Chapter One, the author explains that his is the third book to center on the self-portrait of Montaigne but, unlike one—Miroirs d’encre by Michel Beaujour—his deals only with Montaigne and, unlike both—the other is Montaigne’s Essays (...) as the Book of the Self by Richard Regosin—his is not geared toward literary theory and offers no theoretical approach to self-portraiture or autobiography. What we have, then, is a close textual analysis of the essayist’s self-portrait which is shown to coexist with the ubiquitous voice of the moraliste, whose subject is mankind in general, and a third voice, particularly pronounced in the 1588 and 1595 editions of the Essays, that of the “essayer,” “whose topic is his own book, its aim, its method of inquiry, and its production” (p. 120). Throughout his study, even as he scrutinizes the self-portrait, Brush demonstrates that these three voices are interrelated, interdependent, and virtually inseparable. [End Page 173]Brush’s exhaustive enterprise: to depict “how Montaigne came to the project [of self-portraiture], how he conceived it, how he practiced it, what he had to say about it, what he learned from the strange practice, how it became a way of life for him” (p. 8) takes him into areas that have been well-debated by Montaigne scholars. Thus we find lengthy discussions of the sense of the word “essay,” authorial modesty, the role of the reader, titles, beginnings, digressions, additions, endings, skepticism, nominalism, Catholicism, dialogue, ethics, evolution, the use of personal pronouns, the structure of individual chapters and of the book as a whole, the link between La Boétie’s death and the self-portraiture project, and the interplay between self and other.On each topic, however, Brush inevitably offers a fresh insight, a quirky intuition, or a new departure that makes the discussion worthwhile. He paints the history of both domestic and official portraiture at the moment when Montaigne began writing; he explains why a self-portrait is not an autobiography; he opposes the treatise and the essay; he differentiates clearly between self-study, self-knowledge, and self-portraiture; he depicts what is missing from the portrait that the essayist deemed relatively complete, and he weighs carefully the opposed proclivities of the essayist toward self-improvement and self-acceptance. In addition, he points out how the impossibility of finding a “pure self” forced Montaigne “to paint himself in context” (p. 107) and argues forcefully that the essayist’s “love of life was a profoundly religious experience” (p. 210). In a particularly rich commentary on “Of practice” (pp. 82–83), Brush stresses the importance of writing for the author of the Essays. In this case, the writing of the essay may in fact have been more significant for him than the event that the writing narrates, thus underscoring the essayist’s claim that this book has made him as much as he has made it. Finally, Brush’s tenth chapter, “Study Without a Book,” eloquently elucidates the originality that Montaigne brought to his reading of the ancient adage “Know Thyself.”It was inevitable that Brush would cover much familiar material but by keeping his encyclopedic knowledge of the history of Montaigne criticism in the end notes and by rigorously analyzing the Essays, he has written an eminently readable, jargon-free study that will serve both the beginning student and the seasoned Montaigne scholar. Having no theory to impose, he is free to chart the amazingly rich variety and diversity of the Essays, aspects of the human condition that the essayist always underscored. His book, clearly the product of years of ruminating on the Essays, contains hundreds of quotations from Montaigne’s Travel Journal and from seventy-seven of the one-hundred-seven chapters penned by the essayist. By giving us, in the main, nothing but his own personal reflections on the Essays, he has also curiously and interestingly provided us with his... (shrink)